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**Chloramine-T Overview**:
Chloramine-T (tosylchloramide sodium) is a chlorinated sulfonamide used primarily as a disinfectant and antiseptic, often for topical applications like treating injured skin or disinfecting surfaces. It’s a white or yellowish powder, soluble in water, and commonly used in medical, laboratory, and industrial settings. Its chemical formula is C7H7ClNNaO2S·xH2O (hydrate form), with CAS numbers 127-65-1 (anhydrous) or 7080-50-4 (trihydrate).[](https://www.sigmaaldrich.com/US/en/product/aldrich/857319)[](https://go.drugbank.com/drugs/DB14708)
**Safety Information (assuming "SIN" might relate to safety data)**:
Chloramine-T is classified as a hazardous substance with specific safety considerations:
- **Hazards**:
- **Harmful if swallowed** (H302): LD50 oral (rat) is 935 mg/kg, with risks of severe burns to the mouth, throat, and potential perforation of the esophagus/stomach.[](https://www.sigmaaldrich.com/US/en/sds/SIAL/402869)
- **Causes severe skin burns and eye damage** (H314, H318): It’s corrosive to skin and can cause serious eye damage.[](https://discovery.sdsmanager.com/safety-data-sheet/english/thermo-fisher-scientific-chloramine-t-trihydrate-en/)
- **Respiratory sensitization** (H334): May cause allergy or asthma symptoms if inhaled.[](https://discovery.sdsmanager.com/safety-data-sheet/english/thermo-fisher-scientific-chloramine-t-trihydrate-en/)
- **Irritant**: Moderate to severe irritant to skin and eyes; avoid inhalation of dust or mist.[](https://www.selleckchem.com/msds/MSDS_S6403.pdf)
- **Environmental**: Toxic to aquatic life with long-lasting effects (H411).[](https://www.sigmaaldrich.com/US/en/product/aldrich/857319)
- **Precautionary Measures**:
- Avoid contact with skin, eyes, and clothing (S24/25). Wear protective gloves, clothing, and eye/face protection (S36/37/39).[](https://www.selleckchem.com/msds/MSDS_S6403.pdf)[](https://www.chemsupply.com.au/documents/CL0020_AU.pdf)
- If in eyes, rinse cautiously with water for several minutes and seek medical advice (S26).[](https://www.selleckchem.com/msds/MSDS_S6403.pdf)
- If on skin, remove contaminated clothing and rinse with water (S28).[](https://www.selleckchem.com/msds/MSDS_S6403.pdf)
- Store locked up in a tightly closed container and dispose of according to local regulations (P405, P501).[](https://discovery.sdsmanager.com/safety-data-sheet/english/thermo-fisher-scientific-chloramine-t-trihydrate-en/)
- Use NIOSH/MSHA-approved respirators in poorly ventilated areas (P284).[](https://discovery.sdsmanager.com/safety-data-sheet/english/thermo-fisher-scientific-chloramine-t-trihydrate-en/)
- **First Aid**:
- **Inhalation**: Move to fresh air; provide oxygen or artificial respiration if needed.[](https://www.selleckchem.com/msds/MSDS_S6403.pdf)
- **Skin Contact**: Wash with copious water, remove contaminated clothing, and seek medical attention.[](https://www.selleckchem.com/msds/MSDS_S6403.pdf)
- **Eye Contact**: Rinse with water for several minutes, remove contact lenses if present, and call a physician.[](https://www.selleckchem.com/msds/MSDS_S6403.pdf)
- **Ingestion**: Rinse mouth with water and seek immediate medical attention.[](https://www.selleckchem.com/msds/MSDS_S6403.pdf)
- **Storage and Stability**:
- Stable if stored as directed, away from light, heat, and strong oxidizing agents. Thermal decomposition may release toxic gases like carbon monoxide, nitrogen oxides, or sulfur oxides.[](https://www.selleckchem.com/msds/MSDS_S6403.pdf)
- Keep containers tightly closed to prevent exposure to moisture or air.[](https://www.chemsupply.com.au/documents/CL0020_AU.pdf)
- **Handling**: Should be handled by trained personnel familiar with its hazards, especially in pharmaceutical or laboratory settings.[](https://www.selleckchem.com/msds/MSDS_S6403.pdf)
**Possible Interpretations of "SIN"**:
1. **Safety Information Number**: If "SIN" refers to a safety identifier, the above safety data aligns with standard Material Safety Data Sheets (MSDS) or Safety Data Sheets (SDS) for Chloramine-T, as provided by sources like Merck, Sigma-Aldrich, or Thermo Fisher.[](https://www.sigmaaldrich.com/US/en/product/aldrich/857319)[](https://www.merckmillipore.com/INTL/en/product/msds/MDA_CHEM-102426)[](https://discovery.sdsmanager.com/safety-data-sheet/english/thermo-fisher-scientific-chloramine-t-trihydrate-en/)
2. **Chemical Identifier**: "SIN" could be a typo for "CAS" (Chemical Abstracts Service) number. Chloramine-T’s CAS numbers are 127-65-1 (anhydrous) or 7080-50-4 (trihydrate).[](https://www.selleckchem.com/msds/MSDS_S6403.pdf)
3. **Acronym or Code**: If "SIN" refers to a specific context (e.g., a product code, regulation, or application like "Sistema de Identificación Numérica"), please clarify, as no direct reference to "SIN" appears in the provided Chloramine-T data.
4. **Typo for “SN” or Similar**: If you meant “sodium” (as Chloramine-T is a sodium salt) or another term, please confirm.
**Additional Notes**:
- **Uses**: Chloramine-T is used as a mild disinfectant for skin infections, in laboratory synthesis (e.g., as an oxidizing agent for heterocycle formation), and in some industrial applications. It’s not stable in water-dissolved form, limiting its use in certain contexts.[](https://go.drugbank.com/drugs/DB14708)[](https://www.sigmaaldrich.com/US/en/product/sial/402869)
- **Drug Interactions**: May interact with insulins (increasing hypoglycemia risk) or benzylpenicillin (affecting excretion).[](https://go.drugbank.com/drugs/DB14708)
- **Regulatory Notes**: Classified under GHS as corrosive (Skin Corr. 1B, Eye Dam. 1), acutely toxic (Acute Tox. 4 Oral), and a respiratory sensitizer (Resp. Sens. 1). Comply with local regulations for handling and disposal.[](https://discovery.sdsmanager.com/safety-data-sheet/english/thermo-fisher-scientific-chloramine-t-trihydrate-en/)[](https://veipdisinfectants.com/wp-content/uploads/2023/05/Chloramine-T-Tablets-EN-versie-3.1-export-buiten-EU.pdf)
**Sources**:
- Safety Data Sheets from Sigma-Aldrich, Thermo Fisher, Selleckchem, and Merck.[](https://www.sigmaaldrich.com/US/en/product/aldrich/857319)[](https://www.selleckchem.com/msds/MSDS_S6403.pdf)[](https://discovery.sdsmanager.com/safety-data-sheet/english/thermo-fisher-scientific-chloramine-t-trihydrate-en/)
- DrugBank for Chloramine-T uses and interactions.[](https://go.drugbank.com/drugs/DB14708)
The chemical structure of **Chloramine-T** (tosylchloramide sodium) is as follows:
- **Chemical Name**: Sodium N-chlorotoluene-4-sulfonamide (or sodium N-chlorotosylamide)
- **Molecular Formula**: C₇H₇ClNNaO₂S (anhydrous form) or C₇H₇ClNNaO₂S·3H₂O (trihydrate form)
- **Structure Description**:
- **Core Components**:
- A **toluene** (methylbenzene) ring, which is a benzene ring (C₆H₆) with a methyl group (CH₃) attached at the para position.
- A **sulfonamide group** (-SO₂NH-) bonded to the para position of the toluene ring.
- The nitrogen of the sulfonamide is bonded to a **chlorine atom** (N-Cl), making it an N-chlorinated sulfonamide.
- The sulfonamide group is also coordinated to a **sodium ion** (Na⁺), forming the sodium salt.
- **Structural Representation**:
```
CH₃
|
C₆H₅-SO₂-N(Cl)⁻ Na⁺
```
- The benzene ring (C₆H₅) has a methyl group (CH₃) at the 4-position.
- The sulfonyl group (SO₂) is attached to the benzene ring at the 1-position.
- The nitrogen atom is bonded to the sulfonyl group, a chlorine atom, and carries a negative charge balanced by the sodium cation.
- **2D Structural Diagram**:
```
CH₃
|
_____/ \_____
/ | \
/______|_______\
|
SO₂
|
N⁻Cl
|
Na⁺
```
(Note: The benzene ring is depicted as a hexagon with alternating double bonds, and the methyl group is at the para position relative to the sulfonamide.)
- **Key Features**:
- The **N-Cl bond** is critical for its disinfectant properties, as it releases active chlorine in solution, contributing to its antimicrobial activity.
- The **sodium salt** enhances water solubility, making it practical for aqueous applications.
- In the **trihydrate form**, three water molecules are associated with the molecule, but they do not alter the core structure.
- **Molecular Weight**:
- Anhydrous: ~227.64 g/mol
- Trihydrate: ~281.69 g/mol
If you need a more detailed visualization (e.g., a SMILES notation, 3D model, or specific bond angles), or if you want me to generate an image of the structure (please confirm if so), let me know! Alternatively, I can provide further details on its chemical properties or synthesis.
